Egg P bodies protect maternal mRNA
نویسندگان
چکیده
منابع مشابه
Egg P bodies protect maternal mRNA
Egg P bodies protect maternal mRNA P bodies (processing bodies) are cytoplasmic granules that, in somatic cells, store and degrade mRNAs. But P bodies in the worm egg protect mRNA, according to a study by Boag et al. In a separate study Noble et al. observed that worm eggs have different fl avors of P bodies depending on developmental stage. Boag et al. showed that P bodies in eggs lack an mRNA...
متن کاملP bodies and the control of mRNA translation and degradation.
Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies. Transcripts associated with P body components can either be degraded or return to translation. Moreover, P bodies are also biochemically and functionally related to some maternal and neuronal mRNA granules. This sugge...
متن کاملQuantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage.
The 5'-to-3' mRNA degradation machinery localizes to cytoplasmic processing bodies (P-bodies), which are non-membranous structures found in all eukaryotes. Although P-body function has been intensively studied in yeast, less is known about their role in mammalian cells, such as whether P-body enzymes are actively engaged in mRNA degradation or whether P-bodies serve as mRNA storage depots, part...
متن کاملI-52: Maternal mRNA Metabolism duringOocyte-to-Zygote Transition
Background: Maternal mRNA degradation is a selective process that occurs in waves corresponding to important developmental transitions such as resumption of meiosis, fertilization and zygotic genome activation. It has been demonstrated that the number, position, and combination of 3 UTR cis-acting elements interacting with trans-acting protein factors regulate translation and mRNA stability. Ou...
متن کاملAccumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae.
Recent experiments have shown that mRNAs can move between polysomes and P-bodies, which are aggregates of nontranslating mRNAs associated with translational repressors and the mRNA decapping machinery. The transitions between polysomes and P-bodies and how the poly(A) tail and the associated poly(A) binding protein 1 (Pab1p) may affect this process are unknown. Herein, we provide evidence that ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1823iti5